GMAT GMAT SECTION 3: VERBAL ABILITY Exam (page: 10)
GMAT Section 3: Verbal Ability
Updated on: 09-Feb-2026

Gene therapy offers a new treatment paradigm for curing human disease. Rather than altering the disease phenotype by using agents that interact with gene products, or are themselves gene products, gene therapy can theoretically modify specific genes resulting in disease cure following a single administration. Initially gene therapy was envisioned for the treatment of genetic disorders, but is currently being studied for use with a wide range of diseases, including cancer, peripheral vascular disease, arthritis, Neurodegenerative disorders and other acquired diseases.
Certain key elements are required for a successful gene therapy strategy. The most elementary of these is that the relevant gene be identified and cloned. Upon completion of the Human Genome Project, gene availability will be unlimited. Once identified and cloned, the next consideration must be expression of the gene. questions pertaining to the efficiency of gene transfer and gene expression remain at the forefront of gene therapy research, with current debates revolving around the transfer of desired genes to appropriate cells, and then to obtaining sufficient levels of expression for disease treatment. With luck, future research on gene transfer and tissue-specific gene expression will resolve these issues for the majority of gene therapy protocols.
Other important considerations for a gene therapy strategy include a sufficient understanding of the pathogenesis of the targeted disorder, potential side effects of the gene therapy treatment, and a more in depth understanding of the target cells which are to receive gene therapy.
Gene transfer vector is the mechanism by which the gene is transferred into a cell. Currently there are at least 150 clinical gene therapy protocols worldwide. Since the approval process for these protocols is not as public outside the U.S., it is difficult to ascertain the exact number of worldwide protocols. As of December 1995, 1024 patients had been treated with either a gene transfer or gene therapy protocol. Much controversy exists regarding how many of these patients have benefited from their gene therapy, and no one has yet been cured. Public controversy in the field of human gene therapy is driven by several factors. Ordinary citizens as well as scientists easily understand the enormous potential of gene therapy, but the former may not appreciate all the pitfalls and uncertainly that lie in the immediate future. The financial interests of biotechnology firms and, some have asserted the career interests of some gene therapists have encouraged extravagant, or at least verily optimistic public statements about contemporary gene therapy. In spite of the proliferation of protocols, the actual number of patients treated remains small, and only one genuinely controlled study of human gene therapy has been published as of this date

The author’s attitude toward the gene therapy as a future cure for cancer, peripheral vascular disease, arthritis, Neurodegenerative disorders and other acquired diseases is

Gene therapy offers a new treatment paradigm for curing human disease. Rather than altering the disease phenotype by using agents that interact with gene products, or are themselves gene products, gene therapy can theoretically modify specific genes resulting in disease cure following a single administration. Initially gene therapy was envisioned for the treatment of genetic disorders, but is currently being studied for use with a wide range of diseases, including cancer, peripheral vascular disease, arthritis, Neurodegenerative disorders and other acquired diseases.
Certain key elements are required for a successful gene therapy strategy. The most elementary of these is that the relevant gene be identified and cloned. Upon completion of the Human Genome Project, gene availability will be unlimited. Once identified and cloned, the next consideration must be expression of the gene. questions pertaining to the efficiency of gene transfer and gene expression remain at the forefront of gene therapy research, with current debates revolving around the transfer of desired genes to appropriate cells, and then to obtaining sufficient levels of expression for disease treatment. With luck, future research on gene transfer and tissue-specific gene expression will resolve these issues for the majority of gene therapy protocols.
Other important considerations for a gene therapy strategy include a sufficient understanding of the pathogenesis of the targeted disorder, potential side effects of the gene therapy treatment, and a more in depth understanding of the target cells which are to receive gene therapy.
Gene transfer vector is the mechanism by which the gene is transferred into a cell. Currently there are at least 150 clinical gene therapy protocols worldwide. Since the approval process for these protocols is not as public outside the U.S., it is difficult to ascertain the exact number of worldwide protocols. As of December 1995, 1024 patients had been treated with either a gene transfer or gene therapy protocol. Much controversy exists regarding how many of these patients have benefited from their gene therapy, and no one has yet been cured. Public controversy in the field of human gene therapy is driven by several factors. Ordinary citizens as well as scientists easily understand the enormous potential of gene therapy, but the former may not appreciate all the pitfalls and uncertainly that lie in the immediate future. The financial interests of biotechnology firms and, some have asserted the career interests of some gene therapists have encouraged extravagant, or at least verily optimistic public statements about contemporary gene therapy. In spite of the proliferation of protocols, the actual number of patients treated remains small, and only one genuinely controlled study of human gene therapy has been published as of this date
The primary function of the fifth paragraph is to

Unlike the United States with its generalissimo politicians - Washington, Jackson, Grant, and Eisenhower- the ‘martial arts’ have been conspicuously absent from Canadian politics. The exception to the rule is former Prime Minister Pierre Elliot Trudeau, who became the first Canadian leader to bring a gunslinger ethos to Canadian politics. Trudeau introduced Canada to the refined art of single combat; it was the politics of “doing it my way”. Single-combat confrontation implied much more than the renegade in power did, and far less than the tricks of William Lyon Mackenzie King, prime minister intermittently between 1921 and 1948.
Trudeau’s unique background prepared him for the role of authoritarian leader he would assume later in life. Born on October 18, 1919, Trudeau lived in French-speaking Montreal, but heard English at home from his mother, making it easy for the young politician to appeal to all sectors of Canada, a bilingual country. As a young man, he walked and cycled through Europe, finding himself on occasion on the wrong side of the bars in foreign jails. By 1940, Trudeau entered the law faculty at the University of Montreal. As a student he enlisted in the Canadian Officers Training Corps, where he was given a commission as a lieutenant, a rank he held until his retirement in 1947. Trudeau, a renowned sportsman, held a brown belt in karate, knew how to skin dive and could descend 150 feet off a cliff with ease. He continued performing flamboyant physical feats even in later life as Canada’s fifteenth prime minister, astounding Canadians with his prowess. The public’s adoration made it possible for him to practice his personal brand of ‘do it my way’ politics, initiating profound and long-lasting changes to his country.
Other leaders would never have undertaken to deal with such taboo issues as divorce, abortion and homosexuality– matters likely to infuriate conservative Canada from coast to coast. Even the powerful Mackenzie King dared not touch any of the three, though Trudeau tackled them together in an omnibus bill as Minister of Justice under Lester B. Pearson. His reason for loosening legislation on these issues was, as he put poetically put it, "The state has no business in the bedrooms of the nation." The myths-makers have it that this was Trudeau's first deliberate ‘gun slinging’ move, performed with the ultimate goal of attaining national leadership. Contrary to popular belief, Trudeau had no leadership aspirations at the time; all he had was a passion for combat that eclipsed other religious considerations. Trudeau instigated far-reaching changes in legislation governing divorce, abortion and homosexuality that have had a major impact on Canada, shaping the country into what it is today.

It can be inferred from the passage that former Prime Minister William Lyon Mackenzie King.

Unlike the United States with its generalissimo politicians - Washington, Jackson, Grant, and Eisenhower- the ‘martial arts’ have been conspicuously absent from Canadian politics. The exception to the rule is former Prime Minister Pierre Elliot Trudeau, who became the first Canadian leader to bring a gunslinger ethos to Canadian politics. Trudeau introduced Canada to the refined art of single combat; it was the politics of “doing it my way”. Single-combat confrontation implied much more than the renegade in power did, and far less than the tricks of William Lyon Mackenzie King, prime minister intermittently between 1921 and 1948.
Trudeau’s unique background prepared him for the role of authoritarian leader he would assume later in life. Born on October 18, 1919, Trudeau lived in French-speaking Montreal, but heard English at home from his mother, making it easy for the young politician to appeal to all sectors of Canada, a bilingual country. As a young man, he walked and cycled through Europe, finding himself on occasion on the wrong side of the bars in foreign jails. By 1940, Trudeau entered the law faculty at the University of Montreal. As a student he enlisted in the Canadian Officers Training Corps, where he was given a commission as a lieutenant, a rank he held until his retirement in 1947. Trudeau, a renowned sportsman, held a brown belt in karate, knew how to skin dive and could descend 150 feet off a cliff with ease. He continued performing flamboyant physical feats even in later life as Canada’s fifteenth prime minister, astounding Canadians with his prowess. The public’s adoration made it possible for him to practice his personal brand of ‘do it my way’ politics, initiating profound and long-lasting changes to his country.
Other leaders would never have undertaken to deal with such taboo issues as divorce, abortion and homosexuality– matters likely to infuriate conservative Canada from coast to coast. Even the powerful Mackenzie King dared not touch any of the three, though Trudeau tackled them together in an omnibus bill as Minister of Justice under Lester B. Pearson. His reason for loosening legislation on these issues was, as he put poetically put it, "The state has no business in the bedrooms of the nation." The myths-makers have it that this was Trudeau's first deliberate ‘gun slinging’ move, performed with the ultimate goal of attaining national leadership. Contrary to popular belief, Trudeau had no leadership aspirations at the time; all he had was a passion for combat that eclipsed other religious considerations. Trudeau instigated far-reaching changes in legislation governing divorce, abortion and homosexuality that have had a major impact on Canada, shaping the country into what it is today.

The author of the passage mentions Trudeau’s accomplishments in sports primarily in order to

Unlike the United States with its generalissimo politicians - Washington, Jackson, Grant, and Eisenhower- the ‘martial arts’ have been conspicuously absent from Canadian politics. The exception to the rule is former Prime Minister Pierre Elliot Trudeau, who became the first Canadian leader to bring a gunslinger ethos to Canadian politics. Trudeau introduced Canada to the refined art of single combat; it was the politics of “doing it my way”. Single-combat confrontation implied much more than the renegade in power did, and far less than the tricks of William Lyon Mackenzie King, prime minister intermittently between 1921 and 1948.
Trudeau’s unique background prepared him for the role of authoritarian leader he would assume later in life. Born on October 18, 1919, Trudeau lived in French-speaking Montreal, but heard English at home from his mother, making it easy for the young politician to appeal to all sectors of Canada, a bilingual country. As a young man, he walked and cycled through Europe, finding himself on occasion on the wrong side of the bars in foreign jails. By 1940, Trudeau entered the law faculty at the University of Montreal. As a student he enlisted in the Canadian Officers Training Corps, where he was given a commission as a lieutenant, a rank he held until his retirement in 1947. Trudeau, a renowned sportsman, held a brown belt in karate, knew how to skin dive and could descend 150 feet off a cliff with ease. He continued performing flamboyant physical feats even in later life as Canada’s fifteenth prime minister, astounding Canadians with his prowess. The public’s adoration made it possible for him to practice his personal brand of ‘do it my way’ politics, initiating profound and long-lasting changes to his country.
Other leaders would never have undertaken to deal with such taboo issues as divorce, abortion and homosexuality– matters likely to infuriate conservative Canada from coast to coast. Even the powerful Mackenzie King dared not touch any of the three, though Trudeau tackled them together in an omnibus bill as Minister of Justice under Lester B. Pearson. His reason for loosening legislation on these issues was, as he put poetically put it, "The state has no business in the bedrooms of the nation." The myths-makers have it that this was Trudeau's first deliberate ‘gun slinging’ move, performed with the ultimate goal of attaining national leadership. Contrary to popular belief, Trudeau had no leadership aspirations at the time; all he had was a passion for combat that eclipsed other religious considerations. Trudeau instigated far-reaching changes in legislation governing divorce, abortion and homosexuality that have had a major impact on Canada, shaping the country into what it is today.

The quotation "The state has no business in the bedrooms of the nation," is most probably used to